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Dokumentenidentifikation EP0912095 08.11.2001
EP-Veröffentlichungsnummer 0912095
Titel PHOSPHAT-ZUSAMMENSETZUNG UND IHRE VERWENDUNG
Anmelder Dzneladze, David, Tbilisi, GE;
Dzneladze, Andro, Tbilisi, GE
Erfinder JABISHVILI, Nargiza, Tbilisi, GE
Vertreter derzeit kein Vertreter bestellt
DE-Aktenzeichen 69615714
Vertragsstaaten AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE
Sprache des Dokument EN
EP-Anmeldetag 14.06.1996
EP-Aktenzeichen 969187889
WO-Anmeldetag 14.06.1996
PCT-Aktenzeichen GE9600001
WO-Veröffentlichungsnummer 9747201
WO-Veröffentlichungsdatum 18.12.1997
EP-Offenlegungsdatum 06.05.1999
EP date of grant 04.10.2001
Veröffentlichungstag im Patentblatt 08.11.2001
IPC-Hauptklasse A01N 59/26
IPC-Nebenklasse A61K 33/26   A61K 33/42   C23F 11/18   C23F 11/04   C09D 5/08   C09D 5/18   

Beschreibung[en]

The invention relates to fields such as medicine, agriculture, cattle-raising and construction. The invention deals with water solutions with cold solidification capacity, which are known as mineral adhesives or astringents and are synthesised oxide, phosphate or metal by means of ortho, pyro-, tri-, poly-, or any other phosphorus acid. They can be applied within medicine: surgery, dermatology, dentristry, oncology, pharmacology and other branches. In agricultural use: as a means of curing plant diseases; within veterinary - as a means for preventive maintenance and curing of animal diseases; within construction - as a anticorrosive, fire-resistant, decorative, hydroelectric isolating covers, ceramic tiles, concretes, which protect against radiation, as well as for producing other composite materials.

There are well known compositions which comprise phosphoric acid, iron oxide and metal powder such as e.g. Al (SU - A - 339 090, SU - A - 274 696, SU - A - 364 575). These compositions are used as fillers, cements, fireproof material and paints. There is also known a phosphate composition which contains Fe, Zn, and Mn in phosphoric acid for treating e.g. fungal skin diseases (DE - A - 23 02 216). The disinfecting activity of phosphoric acid is described in DE - A - 30 39 437 and US - A - 4 817 333.

The disadvantages of these compositions are their toxicity, the high cost of production and that they are not effective against a number of microorganisms and viruses.

The proposed invention envisions the reduction of the cost of producing, toxicity and the period of cold solidification through exclusion of polyphosphoric acid and polysacharide from composition contents, as well as exclusion of electric (heat) energy from the technological process.

The substitution of inefficient and expensive polyphosphoric acid with orthophosphoric acid results in a decrease of the composition cost of producing and increases the cold solidification capacity. The synthesis proceeds without supplying electric (heat) energy from outer sources, but rather by means of exothermous reaction ongoing within reaction area which causes the reduction of cost of producing. The exclusion of polysacharide from the contents of the invention results in the decrease of toxicity level.

The phosphate composition is obtained through:

Adding water, while stirring continuously, iron oxide powder and any metal powder for example, aluminium to orthophosphoric acid calculated on 100% acid, for maintenance of temperature regime within the reaction area and for neutralising the extra acidity, the ratio of components in parts by weight being the following: orthophosphoric acid 100 iron oxide 20-41 metal powder 0,5 - 2,5 water 30-70
heat liberated after the exothermal reaction (40°-50°) is enough for dissolution of iron oxide and metal powder which requires holding the mass for 2 hours. The output of the reaction represents transparent, brownish sticky liquid, compactness of which comprises 1.50 g/cm3, while the ratio of phosphate ion to the iron ion equals 2,0 -4,0. The solution is stable for about 2 years.

The iron oxide weight in the proposed invention above 41 will cause the dissolution and solidification of the solution, while below 20, it will result in reducing the cold solidification capacity.

Substitution of aluminium powder by any other metal powder, e.g. Fe, Ca, Mg, Zn, Co, Ni, Y, Sc etc, will alter the composition characteristics, namely, it will either increase or decrease cold solidification capacity.

The metal powder weight above 2.5 in the reaction area will heighten the temperature level to 120°-130° and will result in sticking of dissolved particles and orthopbosphate anion will turn into polyphosphate. If metal powder weight is below 0.5, the temperature within the reaction area remains unaltered and the dissolution is carried at a slow speed, over the period of several days.

The weight of water above or below the normalised level in the reaction area will violate the temperature regime.

The Table 1 and 2 below demonstrate the properties of the iron phosphate solution of a specific composition.

The phosphate composition, unlike its prototype and its analogues is characterised by bactericidal, virucidal and fungicidal properties. The recorded data show that among phosphate admixtures only copper phosphate is characterised by antimicrobial properties and its utilisation in the preparation of fungicides is recommended.

Within the proposed invention the preliminary clinical investigation of the phosphate composition is conducted at the experimental and clinical scientific research laboratory attached to the state Medical University; at the Institute of Labour Hygiene and professional diseases of the Health Ministry of Georgia; at the scientific centre dealing with particularly dangerous infections of the Institute of Sanitary and Hygiene.

The research has revealed that the phosphate composition in water solutions kill the microbes of plague, pseudotuberculosis, salmonella, colibacillus, dysentery, golden staphylococcus microbes, grippe, hepatitis, West Nile fever and oncoviruses (Table 3,4). Within 1-5 minutes after treatment the equipment, clothes, premises, laboratory vessels, patients excrements are sterilised.

As regards its toxicity, it is well known that inorganic admixtures of 5 valence phosphorus are one of the harmless admixtures for humans. Besides, the organism absorbs phosphorus in ortho- form and PO43 anion is considered to be the one of the most significant component of a "physiologically" living organism, which regulates the buffer HPO42- /H2 PO4- system of blood.

The results of toxicological, pathomorphological, histological, pathophysiological, bacteriological, physiological, biochemical, neurological, immunological studies of the phosphate composition have proved that the solution does not alter cardiovascular and respiratory system parameters, neither the functions of liver and kidneys, has no impact on peripheral blood indicators and the immune status of the body, causes no change in cell. There are no indications of allergic reactions. The solution fulfils the deodorant function of dismissing unpleasant odours. Both the phosphate composition and its production processes are ecologically safe.

The abovementioned researches have proved that the solution is neither toxic nor cancerogenic and can be used both for external use and drinking.

The Health Ministry of Georgia has authorised the application of phosphate composition in medicine. The production process is registered at Georgia Standard 13.06.95, the registration number is 15420044-001-95, it is licensed by the Municipality of Tbilisi 19.04.96.

Phosphate composition can serve as: (i) disinfecting means in medicine and in various other fields (veterinary, agriculture, etc); (ii) neutralising premises, inventory, linen, fecal masses for conducting current and final disinfections during bacterial and virus infections; (iii) a means for dealing with objects infected with bactera and viruses and those suspected of being contaminated; (iv) a means for purifying technical, drinking and fecal waters.

The Table 5 (see p. 12) indicates the amount and timing of disinfection of various objects:

The clinical research of phosphate composition is undertaken in the Republic Hospital, in the centre of sepsis and burn treatment, in the institute of urology and skin clinic. It is proved that the phosphate water solutions are characterised by strong capacity (as compared with furacycline) for preventing decomposition and inflammatory processes, of wound healing, analgesic, remedial against scratching and fungous diseases, deodorant properties. Thus it can be served as antiseptic: for treatment of wounds, various damages-burns of the skin, suppurative dermatitis, trophic ulcer, decubitus, broken skin and others. Phosphate composition is used to cure cystitis, nephritis, gastritis, colitis, cholecystitis, vaginitis, erosion, ulcer, conjuctivitis, ceratitis, gingivitis, angina, tonsilitis, pharingytis, dermatitis, eczema, psoriasis, hemorrhoids, burn, suppurative and gangrenous wounds, erysipelas, trophic ulcer, sweating, tumoral formations, oncological diseases.

The phosphate composition water solutions are used in veterinary medicine for curing animal microbial, virus, fungal diseases, such as brucellosis, anthrax, tularemia, plague.

The iron can be used in practice for curing purposes only in its organic admixtures against anaemia. Among these admixtures there are organic admixtures containing phosphorus, such as iron glycerine phosphate - insoluble in water and phytopherolactolirthic organic admixture. Both admixtures are ineffective.

With a view to effectively utilise phosphate composition for curing purposes it is possible to produce a number of preparations of various designation: pills, powders. suppositories, ointments, and ampoules.

Because of its antimicrobic and fungicidal properties, the phosphate composition can be used in agriculture and forestries as a means for fighting plant (vine, crops, fruit, citrus, vegetables) vermins and for curing microbic, virus and fungal diseases.

According to the recorded data phosphate composition materials are building materials, which are produced through warming up the composition above 300°. These materials are the following: fire resistant, thermal isolating, anticorrosive and decorative covers, fire resistant concretes and ceramic mstaials, adhesives etc.

The proposed invention envisions the utilisation of the phosphate composition with cold solidification capacity without thermal treatment.

1. fire-retardant - fire resistant cover, colourless, scentless, transparent water solution, with compactness 1.15 -1.10 g/cm3.

The principle designation of the solution is to cover the surfaces of building materials - wood. metal, conorete as well as textiles and papers with a view to increasing the latters' fire resistance capacity. The treatment is carried out through sprinkling, applying and dipping method. The amount of the solution for 1 m2 equals to 0,2 litres (or 1 litre for 5 m2). After treatment the material surface should be dried up at an indoor temperature under dry environmental conditions during 24 hours.

The solution does not damage the surface, does not alter its colour and material quality. The compactness of wood materials increases by 20-30% after the treatment.

The solution is neither toxic nor carcenogenic. It is fire resistant and is not inflammable. Apartments and and mass assemblage places can by treated with the solution. Its production process is ecologically safe.

The solution is kept in a closed plastic or glass vessel. The vessels are washed with water after usage.

The expiration period of the solution is 3 years.

The fire resistance of the phosphate solution is studied by the fire hazard research department at the Ministry of Internal Affairs. The wooden, textile, paper and metal materials and the paints produced on their surface, after treatment by the solution have withstood the test designed by the state standard and thus they can be referred to as non inflammable materials.

On the basis of the above conclusions the invention related work is registered at Georgia Standard no 150044-002-96 and is licensed by the Tbilisi Municipality.

2. Anticorrosive composition solution

The above solution is used for removing the rust off the metal surface without preliminary mechanical treatment, and for protecting against further rusting. It is composite water solution colourless and scentless. Its compactness equals 1.4 -1.5 g/cm3. It is applied on the rusty surface of the metal either through sprinkling or with a brush. After applying it, the rust is removed from the metal surface and protective coating is formed which can further be painted with any paint or with the same solution after adding pigment.

Anticorrosive coating, with thickness of 80-90 mkm, is characterised by high metal adhesion capacity (70-90 kg/cm2), mechanical solidity (S.106M). temperature resistance (-20° - 500°), independent of changes in the climate conditions. It is not inflammable.

The solution is not toxic and its production process is ecologically safe. The solution is fire resistant and is not explosive. The amount of the solution per 1 m2 surface equals 0.25 litres.

The solution is kept in closed plastic or glass vessel at the indoor temperature, for the period of 4-5 years.

Used instruments and vessels can be washed with water.

3. Phosphate paint

The above paint is used for painting concrete, brick buildings, wooden articles and paper.

The paint is characterised by high decorative properties. independent of changes in the climate or conditions and is a good surface adhesion. Through adding various pigments, it becomes capable of obtaining desirable colours and patterns.

The paint is applied to primed surface. The soii is prepared through diluting the same paint in water with a specific ratio. The paint amount per 1 m2 is 4-5-kg.

The paint is kept in glass or plastic vessel. The expiration period is 2-3 years. The vessels and instruments are washed with water after use.

The paint is not toxic. It is scentless. Its production is ecologically safe. The paint is fire resistant and inflammable.

4. Composite solution for hardening porous minerals

The above composite is 10-20% water solution, colourless and scentless. The compactness of it equals 1.05-1.10 g/cm3. It is characterised by high adhesion capacity towards a range of inorganic materials. It is solidified under any temperature and acquires water-fire resistance (up to 1000°). pbotochemical stability, mechanical solidity. The solution is not toxic. Its production is ecologically safe.

The protective coating is applied to the porous aluminosillicates and materials (sandstone, tufasandstone, concrete, brick etc) with brush or through sprinkling for several times. As a result of two-fold treatment the porosity is reduced by 20-30%, hardness on compression increases by 100-200%. The temperature extension index of the treated stone equals zero.

5. For producing the ceramic materials on the phosphate composition basis, the production waste and mineral raw material processing waste is added to the solution. The materials are obtained through pouring out or pressing, without warming up.

The materials are characterised by high mechanical solidity (hardness) (60), thermal stability up to 2000°, inertness towards aggressive environment and climate changes, dielectiric properties. The shape, colour and pattern could be altered according to the need. example 100% orthophosphoric acid iron oxide kg metal powder kg water kg The ratio of phosphate to iron ion the duration of synthesis hrs temperature of synthesis C° 1 100 28 Al - 1,0 50 3,0 2,0 40 - 50 2 100 41 Al - 2,5 70 2,0 2,5 50 - 60 3 100 20 Al - 0,5 30 4,0 1,5 30 - 40 4 100 32 At - 1,0 60 2,5 2,5 40 - 50 5 100 24 Al - 1,0 40 3,5 1,5 30 - 40 6 100 28 Fe - 1,5 50 3,0 2,0 40 - 50 7 100 41 Zn - 0,5 70 2,0 2,5 40 - 50 8 100 20 Mg - 0,5 30 4,0 1,5 30 - 50
example compactness g/cm3 pH stickiness cp stability in month hardening of composition materials known 1,56-1,60 1,0-2,8 50-120 4-12 thermos treatment 1 1,50 2,70 60 24 indoor temperature 2 1,65 3,5 80 5 indoor temperature 3 1,45 2,0 50 30 thermos treatment 4 1,62 2,5 75 24 indoor temperature 5 1,48 2,50 50 20 indoor temperature 6 1,50 2,70 70 20 indoor temperature 7 1,65 3,5 80 4 indoor temperature 8 1,40 2,0 50 24 thermos treatment
exposure 3 min exposure 5 min control concentration of solution microbes 0.1 0.2 0.3 0.5 1 2.0 0.1 2.0 0.3 0.5 1 2 plague EV + - - - - - - - - - - - + pseudotuberculosis + + + - - - - + + - - - + intestine iersiniosis + + + - - - + + - - - - + salmonella + + + - - - + + - - - + klebsiels + + + - - - + + - - - - + vibrions (cholera) + - - - - - - - - - - - + dysentery + - - - - - - - - - - - + colibacillus + + + + - - + + + - - - + golden staphylococcus + + + + - - + + + + - - + anthrax + + + - - - + + - - - - + brucellosis + + + - - - + + - - - - +
exposure 3 min exposure 5 min concentration of solution virus 0.01 0.02 0.05 0.1 0.2 0.50 1 0.01 0.02 0.05 0.1 0.2 0.5 1 West Nile Fever + - - - - - - - - - - - - + grippe + + + - - - - + + - - - - - coxsac B + + + + - - - + + + + - - - hepatitis A + + + + + + + + + + + + + - plague phage - - - - - - - - - - - - - - pseudotuberculosis - - - - - - - - - - - - - - oncovirus + + + - - - - - + - - - - -
OBJECT solution amount timing treatment premises and bard inventory 500ml/m2 10 sprinkling, cleaning lavatory pan, reservoir, bath tube, floor sweeper 500ml/m2 1.0 sprinkling, cleaning fluid extracts: urine etc twice more 1.0 pouring, spraying window panes, tables, furniture linen, gowns, masks, gloves, rubber boots 300ml/m2 1.0 sprinkling, cleaning patients' vessels 5lit/1kg 10 placing in solution laboratory vessels: china, glass, metal 5 cleaning hands and other exposed parts of body 2 lit/1 set 1.0 placing in solution instruments after dissection 1.0 placing in solution vivarium premises 5 washing 1.0 placing in solution 300ml/m2 1.0 sprinkling
Comparison of disinfectant solution "Nargosept" to other disinfecting solutions, containing chlorine, phenolic and quat. ammonium chloride compounds Quality Chlorine preparations Phenolic Quat. ammonium chloride "Nargosept" 1. Toxicity yes yes yes no 2. Cancerogenic yes yes yes no 3. Allergic yes yes yes no 4. Scent strong specific scent yes scentless 5. Stability evaporative, not stable evaporative evaporative stable for 5-6 years 6. Influence on mucous membrane causes strong irritation acute inflammation inflammation, burns no influence 7. Influence on skin burns, causes dermatitis acute inflammation, necrosis redness, burns no influence 8. Influence on eyes irritates, causes conjunctivitis irritates, causes conjunctivitis irritates no influence 9. Influence on respiratory ducts irritates, causes laryngitis and pharyngitis irritates, causes laryngitis and pharyngitis irritates no influence 10. Influence on central nervous sys. dizziness, vomiting and loss of orientation paralysis of C.N.S yes no influence 11. Poisoning causes acute poisoning causes acute poisoning yes no influence 12. Bactericidal and virucidal yes 10 min. yes 10 min. yes 10 min. yes 5 min. 13. Changes in Blood causes leucocytosis thromboses yes no influence 14. Influence on lungs causes inflammation causes inflammation yes, inflames no influence 15. Influence on kidney strongly nephrotoxic nephrotoxic nephrotoxic no influence 16. Usage at home, hospitals, schools, and other institutions impossible impossible with caution can be used safely
properties on concrete asbestos cement slate steel -3 known optimal option known optimal option known optimal option known optimal option water resistance water soluble P2O3. % 0.01 - 0.05 - - - 0.05 - atmospheric stability month 6 60 6 60 6 48 6 36 solidity, (hardness) 3% in NaCl, month 1 4 1 3 1 3 1 3 solidity (hardness) on Impact kg/cm2 40 70 50 60 30 60 30 50 solidity (hardness) on adhesion 2 3.6
Definition of solidification period contents of the composition massive % compression hardness pH of pressed out water Delay hours 24 48 72 96 120 24 48 72 96 120 iron phosphate composition andesite- 70 prototype 1.2 1.8 2.2 2.5 2.5 4.5 5.2 5.9 6.5 6.5 optimal option 25 25 3.0 3.0 3.0 5.0 5.5 6.5 6.5 6.5 iron phosphate composition andesite - 70 kaoline - 10 prototype 1.8 2.5 3.5 4.0 4.0 4.0 5.5 6.5 7.0 7.0 optimal option 4.0 4.0 5.5 5.5 5.5 5.0 5.5 6.5 .5 6.5 iron phosphate composition andesite - 80 prototype 0.2 0.3 0.5 0.5 0.5 3.0 3.0 3.0 3.5 3.5 optimal option 3.5 4.0 4.5 4.5 4.5 5.5 5.5 6.0 6.5 6.5 iron phosphate composition andesite - 80 (warmed up to 400°) prototype 4.0 - - - - 7.0 7.0 - - - optimal option 5.0 5.0 5.0 5.0 5.0 7.0 7.0 7.0 7.0 7.0

List of References

  • 1. Kopein V.A. "The Material in regard to metalophosphate basis" Moscow, Publishing House "Chemistry", 1976, pp. 50-54.
  • 2. Korbridge D. Phosphorus. Moscow, 1982, pp. 130-141.
  • 3. USSR Copyright No 968005, 1992.
  • 4. USSR Copyright, No 1564281, 1991.
  • 5. Sichev M.M. Inorganic Adhesives, Leningrad, Publishing House "Chemistry", 1996, pp. 117-125.


Anspruch[de]
  1. Phosphat-Zusammensetzung enthaltend Orthophosphorsäure, Eisenoxid, ein Metallpulver und Wasser, umfassend die folgenden Inhaltsstoffe in Gewichtsteilen: Orthophosphorsäure 100 Eisenoxid 20 - 41 Metallpulver 0,5 - 2,5 Wasser 30 - 70.
  2. Zusammensetzung gemäß Anspruch 1, worin das Metallpulver ausgewählt ist aus der Gruppe bestehend aus Aluminium-, Magnesium-, Zink-, Calcium-, Kobalt-, Yttrium-, Nickel- und Scandiumpulver.
  3. Verwendung der Zusammensetzung gemäß Anspruch 1 zur Herstellung von antimikrobiellen, antiviralen und fungiziden Medikamenten zur Behandlung von Menschen und Tieren.
  4. Verwendung der Zusammensetzung gemäß Anspruch 1 zur Herstellung von Medikamenten zur Behandlung von entzündlichen Prozessen und Pilzerkrankungen.
  5. Verwendung der Zusammensetzung gemäß Anspruch 1 zur Herstellung von Zubereitungen zur Behandlung und Vorbeugung von Pilz- und mikrobiellen Erkrankungen bei Pflanzen.
  6. Verwendung der Zusammensetzung gemäß Anspruch 1 zur Herstellung eines sich kalt verfestigenden Haftbindemittels zur Herstellung von feuerfesten, korrosionshemmenden, Feuchtigkeits- und Elektrizitäts-isolierenden und gegen Strahlung schützenden Überzügen ohne thermische Behandlung.
Anspruch[en]
  1. Phosphate composition containing orthophosphoric acid, iron oxide, a metal powder and water, comprising the following ingredients in parts by weight orthophosphoric acid 100 iron oxide 20 - 41 metal powder 0,5 - 2,5 water 30 - 70.
  2. The composition according to claim 1, wherein the metal powder is selected from the group consisting of aluminium, magnesium, zinc, calcium, cobalt, yttrium, nickel and scandium powders.
  3. Use of the composition according to claim 1 for the manufacture of antimicrobial, antiviral and fungicidal medicaments for human and veterinary treatment.
  4. Use of the composition according to claim 1 for the manufacture of medicaments for treatimg inflammatory processes and fungal diseases.
  5. Use of the composition according to claim 1 for the manufacture of preparations for treating and preventing fungal and microbial diseases in plants.
  6. Use of the composition according to claim 1 for the manufacture of cold solidification adhesive binder for production of fire resistant, anticorrosive, hydro and electric isolating and protecting against radiation covers without thermal treatment.
Anspruch[fr]
  1. Composition à base de phosphate contenant de l'acide orthophosphorique, de l'oxyde de fer, une poudre métallique et de l'eau, comprenant les ingrédients suivants en parties en poids acide orthophosphorique 100 oxyde de fer 20-41 poudre métallique 0,5 - 2,5 eau 30 - 70.
  2. Composition selon la revendication 1, dans laquelle la poudre métallique est sélectionnée dans le groupe constitué de poudres d'aluminium, de magnésium, de zinc, de calcium, de cobalt, d'yttrium, de nickel et de scandium.
  3. Utilisation de la composition selon la revendication 1 pour la production de médicaments antimicrobiens, antiviraux et fongicides destinés à un traitement en médecine humaine et en médecine vétérinaire.
  4. Utilisation de la composition selon la revendication 1 pour la préparation de médicaments destinés au traitement de processus inflammatoires et de mycoses.
  5. Utilisation de la composition selon la revendication 1 pour la production de préparations destinées au traitement et à la prévention de mycoses et de maladies microbiennes dans les plantes.
  6. Utilisation de la composition selon la revendication 1 pour la production d'un liant adhésif à solidification à froid pour la production de revêtements ignifuges, anticorrosion, hydrofuges et à isolation électrique et de protection contre les rayonnements, sans traitement thermique.






IPC
A Täglicher Lebensbedarf
B Arbeitsverfahren; Transportieren
C Chemie; Hüttenwesen
D Textilien; Papier
E Bauwesen; Erdbohren; Bergbau
F Maschinenbau; Beleuchtung; Heizung; Waffen; Sprengen
G Physik
H Elektrotechnik

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