PatentDe  


Dokumentenidentifikation EP0915654 15.05.2003
EP-Veröffentlichungsnummer 0915654
Titel VERFAHREN UND ZUSAMMENSETZUNG FÜR DIE ANTIPARASITÄRE BEHANDLUNG DER UMGEBUNG VONTIEREN
Anmelder Bayer CropScience S.A., Lyon, FR
Erfinder SMITH, William, James, Raleigh, US;
YENNE, Perry, Samuel, Raleigh, US
Vertreter Beetz & Partner, 80538 München
DE-Aktenzeichen 69720731
Vertragsstaaten AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LI, LU, NL, PT, SE
Sprache des Dokument EN
EP-Anmeldetag 17.07.1997
EP-Aktenzeichen 979355260
WO-Anmeldetag 17.07.1997
PCT-Aktenzeichen PCT/EP97/03828
WO-Veröffentlichungsnummer 0098003070
WO-Veröffentlichungsdatum 29.01.1998
EP-Offenlegungsdatum 19.05.1999
EP date of grant 09.04.2003
Veröffentlichungstag im Patentblatt 15.05.2003
IPC-Hauptklasse A01N 47/02

Beschreibung[en]

The present invention relates to a process for the antiparasitic treatment of the surroundings of animals, in particular of animal litter and of rearing buildings, in particular for the purpose of protecting them against parasites from the darkling beetle family.

In the present text, animal litter is taken in the broad sense, that is to say that this term comprises beds made of plant or other material on which the animals lie or gather, including open-air sites or places, in particular those of the "feed lot" type in North America.

The invention also encompasses the treatment of liquid manure, in particular in the vicinity of animal rearing sites. The invention applies to the litter and liquid manure of all types of animals but is very particularly applied in the avian field (in particular chickens, turkeys, guinea fowls, ducks, geese and laying hens). The invention also applies to ready-to-use litter or to litter components treated by the process according to the invention.

The intensive rearing of animals intended for consumption results in a large number of animals being confined in a restricted space. This applies both to small animals, such as poultry and rabbits and others, and to large animals, such as cattle, pigs and the like.

Broilers are, for example, reared for 8 weeks on average. Between two groups, that is to say between two rearing cycles, the breeder generally cleans the site, with the site being left empty for several days for health reasons.

However, the frequency at which breeders clean the rearing area and more particularly the litter is always limited by rearing requirements. Animal rearing sites are therefore centres for the development of parasites in the general sense, including insects. This naturally has a direct impact on the sanitary condition of the sites and on the health of the animals and indirectly on rearing productivity.

Poultry litter is basically composed of materials of plant origin, such as, for example, sawdust or wood chippings, with which dejecta or excrement from the animals will be mixed in time. As the litter is not changed at each rearing cycle, the thickness of the soiled litter frequently reaches several tens of centimetres. In particular, beetles from the Tenebrionidae family, also known as darkling beetles, develop therein. The treatment of poultry litter is a problem which is particularly difficult to solve in that any product used to treat this litter has a tendency to be absorbed by the litter, either by the excrement which is found therein or by the plant matter which is found therein. Moreover, the continuous arrival of fresh excrement tends to isolate the insecticidal materials from the site to be treated.

Darkling beetles comprise various species. One of the main species is Alphitobius diaperinus; this species is particularly well controlled by the present invention. Another darkling beetle species is Tenebrio molitor. Another species of parasite which infests poultry litter is Dermestes maculatus.

The presence of these parasites, especially darkling beetles, has two impacts with serious economic consequences.

The first impact is on the growth of the poultry. In poultry rearing, the speed of the rearing cycle is an economically determining factor and the least disturbance to food intake has consequences for the growth of the animals. Now, these beetles are ingested by poultry, and particularly by chicks, and they can then cause slow-down in growth.

The second impact is on the very structure of the rearing buildings. In fact, at the adult stage, in particular between two rearing cycles, the adult beetles can ascend into the structures of the buildings and lay their eggs there. The larvae, before redescending into the litter, have a tendency to devour the heat-insulation materials, such as polystyrene. Now, poultry is very sensitive to the temperature, so that the consequences of such a deterioration can be catastrophic with respect to the progression of the rearing. The rearing buildings must therefore frequently be repaired or replaced.

Laying hens and rabbits are both raised on gratings and their dejecta or excrement are continuously discharged and generally stored in the vicinity of the rearing buildings. The liquid manure which thus accumulates itself also exhibits the disadvantages cited above with respect to the sanitary condition of the sites and the health of the animals.

Another problem frequently encountered is the presence of flies, in particular the house fly, the larvae of which develop within the soiled litter and the liquid manure. These flies are a nuisance both to animals and to man, in and in the vicinity of the animal rearing site. In addition, these flies can be the vector for infectious agents and can be responsible for epidemic pathologies.

Darkling beetles are insects/parasites which are particularly difficult to remove. This difficulty is illustrated by the fact that there is only a single product which has been successful commercially: this is the product known under the name of carbaryl [1-naphthyl methylcarbamate]. This is all the more surprising since this product is an old product, being at least forty years old, and although a number of insecticides have been developed since, none has been in a position to supplant carbaryl with respect to poultry. Unfortunately, carbaryl is a product which, in a number of respects, has a limited performance, both as regards effectiveness and as regards the duration of this effectiveness. An explanation for this currently existing lack of worthwhile products probably results from the difficulty of treating animal litter, as has been explained above.

A first object of the invention is to provide a process and compositions which can completely or partially solve the problems indicated above.

According to another aspect, a subject of the present invention is a process for the antiparasitic treatment of sites infested or capable of being infested by darkling beetles, in which an effective amount of a composition comprising carbaryl and at least one compound corresponding to the formula (I) is applied to the said site, the said sites comprising floors, litter, liquid manure or the like.

According to another aspect, a subject of the present invention is a process for the antiparasitic treatment of rearing places or buildings, in particular for commercial rearing, in particular of poultry, and more especially of sites infested or capable of being infested by darkling beetles, the said process comprising the application to the said site of an effective amount of a composition comprising carbaryl and at least one compound corresponding to the formula (I).

According to another aspect, the invention relates to a means for combating darkling beetles or insects from the Tenebrionidae family, especially Alphitobius diaperinus, the said process comprising the application to the sites infested or capable of being infested by the said darkling beetles of an effective amount of a composition comprising carbaryl and at least one compound corresponding to the formula (I).

Another object of the invention is to provide means for combating the insects known under the name of Dermestes maculatus, the said process comprising the application to the sites (floors, litter, liquid manure places or buildings) of an effective amount of a composition comprising carbaryl and at least one compound corresponding to the formula (I).

The present invention further relates to a process for the antiparasitic treatment of the surroundings of animals, in particular of sites infested or capable of being infested by a parasite from the group composed of a darkling beetle and/or Alphitobius diaperinus and/or Dermestes maculatus and/or Tenebrio molitor, the said treatment comprising the application to the said surroundings or to the said site of an effective amount of a composition comprising carbaryl and at least one compound corresponding to the formula (I). According to one aspect of this invention, these infested sites or sites capable of being infested are floors, litter or liquid manure or the like. According to another aspect, these sites are commercial rearing places or buildings.

The present invention therefore further relates to a process for the antiparasitic treatment of sites infested or capable of being infested by an insect from the group composed of darkling beetles and/or Alphitobius diaperinus and/or Dermestes maculatus and/or Tenebrio molitor, in which an effective amount of a composition comprising carbaryl and at least one compound corresponding to the formula (I) is applied to the said site, the said process being carried out at a frequency of less than once per month.

The present invention therefore further relates to a process for the antiparasitic treatment of sites infested or capable of being infested by an insect from the group composed of darkling beetles and/or Alphitobius diaperinus and/or Dermestes maculatus and/or Tenebrio molitor, in which an effective amount of a composition comprising carbaryl and at least one compound corresponding to the formula (I) is applied to the said site, the said process being carried out at a frequency not exceeding once per rearing cycle.

The products of formula (I) used in the invention are products, the formula of which is:

in which:
R1
is a halogen atom or a CN or methyl group;
R2
is S(O)nR3 or 4,5-dicyanoimidazol-2-yl or haloalkyl;
R3
is alkyl or haloalkyl;
R4
represents a hydrogen or halogen atom; or an NR5R6, S(O)mR7, C(O)R7 or C(O)O-R7, alkyl, haloalkyl or OR8 radical or an -N=C(R9)(R10) radical;
R5 and R6
independently represent a hydrogen atom or an alkyl, haloalkyl, C(O)alkyl, alkoxycarbonyl, S(O)rCF3 radical; or R5 and R6 can together form a divalent alkylene radical which can be interrupted by one or two divalent heteroatoms, such as oxygen or sulphur;
R7
represents an alkyl or haloalkyl radical;
R8
represents an alkyl or haloalkyl radical or a hydrogen atom;
R9
represents an alkyl radical or a hydrogen atom;
R10
represents a phenyl or heteroaryl group optionally substituted by one or a number of halogen atoms or groups such as OH, -O-alkyl, -S-alkyl, cyano or alkyl;
R11 and R12
represent, independently of one another. a hydrogen or halogen atom and optionally CN or NO2 but H or halogen are preferred;
R13
represents a halogen atom or a haloalkyl, haloalkoxy, S(O)qCF3 or SF5 group;
m, n, q and r
represent, independently of one another, an integer equal to 0, 1 or 2;

X represents a trivalent nitrogen atom or a C-R12 radical, the other three valencies of the carbon atom forming part of the aromatic ring;

with the proviso that, when R1 is methyl, then either R3 is haloalkyl,
R4
is NH2, R1 is Cl, R13 is CF3 and X is N; or else R2 is 4,5-dicyanoimidazol-2-yl,
R4
is Cl, R11 is Cl, R13 is CF3 and X is =C-Cl.

The alkyl radicals of the definition of the formula (I) generally comprise from 1 to 6 carbon atoms. The ring formed by the divalent alkylene radical representing R5 and R6 and by the nitrogen atom to which R5 and R6 are attached is generally a 5-, 6- or 7- membered ring.

A preferred class of compounds of the formula (I) comprises the compounds such that R1 is CN and/or R3 is haloalkyl and/or R4 is NH2 and/or X is CR12 and/or R11 and R12 are, independently of one another, a halogen atom and/or R13 is haloalkyl.

A compound of formula (I) which is very particularly preferred in the invention is 1-[2,6-Cl2-4-CF3phenyl]-3-CN-4-[SO-CF3]-5-NH2pyrazole, hereinafter known as compound A.

Compounds of formula (I) can be prepared according to one or other of the processes described in Patent Applications WO 87/3781, 93/6089 or 94/21606 or European Patent Applications 295,117, 403,300, 385,809 or 679,650 or German Patent Application 19511269 or in US Patents 5,232,940 and 5,236,938 or any other process coming within the competence of the person skilled in the art who is an expert in chemical synthesis. For the chemical preparation of the products of the invention, the person skilled in the art is regarded as having available, inter alia, all the contents of "Chemical Abstracts" and of the documents which are cited therein. Compositions comprising the compounds of formula (I) can also be prepared according to the teaching of this same prior art or of a similar prior art.

According to another aspect of the present invention, the latter relates to pesticidal compositions intended to be used in the processes defined above. These pesticidal compositions comprise at least one active compound of formula (I) mixed with solid or liquid vehicles and/or surface-active agents, these various constituents being acceptable in agriculture and/or in aviculture and/or in the veterinary field and/or, preferably, in the field of animal rearing. In particular, the inert and conventional vehicles and the conventional surface-active agents can be used.

The compositions used in the invention can either be compositions, generally diluted, which are ready to be applied to the site infested or capable of being infested by the parasite or can be concentrated compositions (better suited to commercialization or storage), which have to be diluted before application. The dilute composition can be prepared either by diluting with water from a commercial concentrated composition containing the active material (the concentrated mixture being called "ready mix") or by means of the mixture prepared at the time of use (called "tank mix") of compositions separately comprising the various constituents or vehicles.

The compositions used in the invention can also contain any kind of other ingredients such as, for example, protective colloids, adhesives, thickening agents, thixotropic agents, penetrating agents, stabilizing agents, sequestering agents and the like. More generally, these compositions can be combined with all the solid or liquid additives corresponding to the conventional formulating techniques.

Generally, the compositions according to the invention usually contain from 0.00001 to 95 % of active material(s) of formula (I), preferably 0.5 to 90 % for the concentrated compositions.

Except when otherwise indicated, the percentages given in the present account are percentages by weight.

In the present account, the term "vehicle" denotes a natural or synthetic, organic or inorganic material with which the active material(s) is combined to facilitate its application to the parts of the plant. This vehicle is thus generally inert and it must be acceptable in agriculture and/or in aviculture and/or in the veterinary field and/or, preferably, in the field of animal rearing. The vehicle can be solid (clays, natural or synthetic silicates, silica, resins, waxes, solid fertilizers and the like) or liquid (water, alcohols, especially butanol, and the like).

The surface-active agent can be an emulsifying, dispersing or wetting agent of ionic or nonionic type or a mixture of such surface-active agents. There may be mentioned, for example, salts of polyacrylic acids, salts of lignosulphonic acids, salts of phenolsulphonic or naphthalenesulphonic acids, polycondensates of ethylene oxide with fatty alcohols or with fatty acids or with fatty amines, substituted phenols (especially alkylphenols or arylphenols), salts of esters of sulphosuccinic acids, taurine derivatives (especially alkyltaurates), phosphoric esters of polyoxyethylenated phenols or alcohols, esters of fatty acids and of polyols, and the derivatives of the above compounds containing sulphate, sulphonate and phosphate functional groups. The presence of at least one surface-active agent is generally indispensable when the active material(s) and/or the inert vehicle is/are not soluble in water and when the carrier agent for application is water.

The surface-active agent content of the compositions according to the invention is advantageously between 2 % and 40 %.

The compositions according to the invention can be in fairly diverse, solid or liquid forms.

There may be mentioned, as forms of solid compositions, powders for dusting, wettable powders (or powder to be sprayed with water) and granules, in particular water-dispersible granules.

Wettable powders (or powder to be sprayed) generally contain 1 to 90 % of active material(s), as well as, in addition to the solid vehicle, from 1 to 30 % of a wetting agent, from 2 to 20 % of a dispersing agent and, when this is necessary, from 0.1 to 10 % of one or more stabilizing agents and/or other additives, such as penetrating agents, adhesives, or anticlumping agents, dyes, and the like.

To obtain powders to be sprayed or wettable powders, the active materials are intimately mixed, in suitable mixers, with the additional substances and the mixture is milled with mills or other suitable grinders. Powders to be sprayed are thereby obtained with advantageous wettability and suspensibility; they can be suspended in water at any desired concentration and these suspensions can be used very advantageously, in particular for application, for example, to litter.

Various compositions of wettable powders (or powders to be sprayed) are given here as examples:

WP Example 1:

  • active material(s)   50 %
  • ethoxylated fatty alcohol (wetting agent)   2.5 %
  • ethoxylated phenylethylphenol (dispersing agent)   5 %
  • chalk (inert vehicle)   42.5 %

WP Example 2:

  • active material(s)   10 %
  • C13 branched-type synthetic oxo alcohol, ethoxylated with 8 to 10 molecules of ethylene oxide (wetting agent)   0.75 %
  • neutral calcium lignosulphonate (dispersing agent)   12 %
  • calcium carbonate (inert filler)   q.s. for 100 %

WP Example 3:

This wettable powder contains the same ingredients as in the above example, in the proportions below:

  • active material(s)   75 %
  • wetting agent   1.50 %
  • dispersing agent   8 %
  • calcium carbonate (inert filler)   q.s. for 100 %

WP Example 4:

  • active material(s)   90 %
  • ethoxylated fatty alcohol (wetting agent)   4 %
  • ethoxylated phenylethylphenol (dispersing agent)   6 %

WP Example 5:

  • active material(s)   50 %
  • mixture of anionic and nonionic surface-active agents (wetting agent)   2.5 %
  • sodium lignosulphonate (dispersing agent)   5 %
  • kaolin clay (inert vehicle)   42.5 %

Aqueous dispersions and emulsions, for example the compositions obtained by diluting a wettable powder according to the invention with water, come within the general scope of the present invention. Emulsions can be of the water-in-oil or oil-in-water type and they can have a thick consistency, like that of a "mayonnaise".

The compositions according to the invention can be formulated in the form of granules, in particular of water-dispersible granules.

The granules can be obtained by extrusion, by compacting, by impregnation of a granulated vehicle or by granulation from a powder (the active material content in these granules being between 0.5 and 85 % for the latter cases).

The water-dispersible granules, with a bulk density generally of between approximately 0.2 and 0.8 (preferably 0.3 to 0.6), have a particle size generally of between approximately 0.1 and 3 mm and preferably between 0.3 and 1.5 mm.

The active material content of these granules is generally between approximately 1 % and 90 %, and preferably between 25 % and 85 %.

The remainder of the granule is essentially composed of a solid filler and. optionally, of surface-active adjuvants which confer water-dispersibility properties on the granule. These granules can be essentially of two distinct types according to whether the filler used is soluble or insoluble in water. The filler can be inorganic or organic. Excellent results were obtained with urea. Kaolin or bentonite can also be used. The granules advantageously comprise surface-active agents (in a proportion of 2 to 20 % by weight of the granule), of which more than half consists of, for example, at least one dispersing agent, essentially anionic, such as an alkali metal or alkaline-earth metal polynaphthalenesulphonate or an alkali metal or alkaline-earth metal lignosulphonate, the remainder consisting of nonionic or anionic wetting agents such as an alkali metal or alkaline-earth metal alkylnaphthalenesulphonate.

Moreover, although this is not indispensable, it is possible to add other adjuvants such as antifoaming agents.

The granule according to the invention can be prepared by mixing the necessary ingredients and then granulating according to several techniques known per se (granulator, fluid bed, atomizer, extrusion, and the like). The preparation generally finishes with a crushing followed by a sieving to the particle size chosen within the limits mentioned above. It is also possible to use granules obtained as above and then impregnated with a composition containing the active material(s).

It is preferably obtained by extrusion, by carrying out the preparation as indicated in the examples below.

DG Example 1: Dispersible granules

90 % by weight of active material(s) and 10 % of urea in the form of pearls are mixed in a mixer. The mixture is then milled in a pin mill. A powder is obtained which is moistened with approximately 8 % by weight of water. The moist powder is extruded in a perforated-roller extruder. A granule is obtained which is dried, and then crushed and sieved, so as to retain respectively only the granules having a size of between 0.15 and 2 mm.

DG Example 2: Dispersible granules

The following constituents are mixed in a mixer:

  • active material(s)   75 %
  • wetting agent (sodium alkylnaphthalenesulphonate)    2 %
  • dispersing agent (sodium polynaphthalenesulphonate)    8 %
  • water-insoluble inert filler (kaolin)   15 %

This mixture is granulated on a fluid bed in the presence of water and then dried, crushed and sieved so as to obtain granules having a size of between 0.15 and 0.80 mm.

DG Example 3: Dispersible granules

The following constituents are mixed in a mixer:

  • active material(s)   80 %
  • wetting agent (dioctyl sodium sulphosuccinate)   2 %
  • dispersing agent (sodium polycarboxylate)   5 %
  • antifoaming agent (silicone oil)   0.3 %
  • alkaline lignosulphonate   2.7 %

This mixture is granulated on a fluid bed in the presence of water and then dried, crushed and sieved so as to obtain granules having a size of between 0.15 and 0.80 mm.

These granules can be used alone or in solution or dispersion in water so as to obtain the required dose. They can also be used to prepare combinations with other active materials, the latter being in the form of wettable powders, or of aqueous suspensions or granules.

There may be mentioned, as forms of liquid compositions or those intended to constitute liquid compositions at the time of application, solutions, in particular water-soluble concentrates, emulsions, emulsifiable concentrates or suspension concentrates, which can be suspoemulsions (suspensions of a solid in a liquid emulsion).

The suspension concentrates, applicable by spraying, are prepared so as to obtain a stable fluid product which does not settle out and they generally contain from 5 to 75 % of active material(s), from 0.5 to 25 % of surface-active agents, from 0.1 to 10 % of thixotropic agents and from 0 to 10 % of suitable additives, such as antifoaming agents, corrosion inhibitors, stabilizing agents, penetrating agents and adhesives and, as vehicle, water and/or an organic liquid in which the active material(s) is/are insoluble or nearly insoluble: certain organic solid materials or inorganic salts can be dissolved in the vehicle to aid in preventing sedimentation or as antigels for water.

These suspension concentrates used in the invention preferentially comprise 10 to 35 % of active material of formula (I), 20 to 40 % of water, 20 to 40 % of vegetable oil and 2 to 20 % of surface-active, wetting or dispersing agents, in particular salts and esters of ethoxylated polystyrylphenols and ethoxylated alkylphenols.

A suspension concentrate composition is given here as an example:

SC Example 1:

  • active material(s)   500 g
  • polyethoxylated tristyrylphenyl phosphate   50 g
  • polyethoxylated alkylphenol   50 g
  • sodium polycarboxylate   20 g
  • ethylene glycol   50 g
  • organopolysiloxane oil (antifoaming agent)   1 g
  • polysaccharide   1.5 g
  • water   316.5 g

SC Example 2:

  • active material(s)   200 g
  • polyethoxylated tristyrylphenyl phosphate   100 g
  • polyethoxylated alkylphenol   79 g
  • sodium polycarboxylate   20 g
  • organopolysiloxane oil (antifoaming agent)   1 g
  • water   300 g
  • sunflower or soya oil   300 g

The invention also relates to the method of application of the compositions described above. For the process for the treatment of floors, litter and liquid manure, it is preferable to use granules, in particular water-dispersible granules. For non-horizontal sites, in particular the parts of buildings other than the floors, it is preferable to spray dilute liquid formulations, which can be obtained from solid or liquid concentrated compositions, preferably by dilution with water.

As regards the application of solid formulations, in particular of granules, to floors, litter or liquid manure, it is possible to use several tens of grams of the composition for treating an animal rearing site with an area of 2000 m2, in particular between 0.5 and 5 g per 100 m2, depending on the concentration of compound (1) in the granules.

It is preferable to dissolve or disperse the granules in a suitable volume of water in order to treat the places, which can advantageously be done by spraying.

In accordance with this embodiment, it is also possible, after having spread the granules over the floor, to moisten the latter.

In the present application, when speaking of dissolving the granules in water, this must, of course, be understood as the dissolution of the excipient which forms the granules, the compound (I) then becoming dispersed in this water.

According to a second preferred embodiment of the invention, use is made of a suspension obtained by diluting a suspension concentrate or an emulsified concentrate of compound (I) in a given volume of water.

The amount of compound of formula (I) applied is generally between 0.05 and 100 mg per m2, in particular preferably between 0.5 and 50 mg/m2 and more preferentially still between 10 and 15 mg/m2.

Generally, the volume of composition applied per m2 can be between 0.1 and 1 litre.

Generally, the application of the compositions according to the invention is preferably carried out in the absence of animals.

The invention is applied not only in the treatment of litter and liquid manure associated with small animals in intensive rearing but also in the rearing of large animals, in particular cattle, and in all cases of grouping together animals, in particular animals for rearing. Mention may be made, for example, of the "feed lot" of North America, which is an open-air grouping together of a large number of cattle (for example 1000 to 20,000) over a period of 1 to several months before slaughter.

Another subject of the invention is a process for combating darkling beetles according to the characteristics described above relating to the process for the treatment of the various sites (floors, litter, liquid manure, places or buildings).

A further subject of the invention is a ready-to-use litter or a litter with litter components which are capable of being obtained by the process according to the invention. In other words, the invention also relates to such products comprising at least one compound according to the invention, in particular at a dose of 0.01 to 50 mg/kg of ready-to-use litter, preferably of 0.1 to 10 mg/kg.

According to another aspect of the present invention, the latter relates to pesticidal compositions, especially insecticidal compositions, comprising an active compound of formula (I) [preferably the compound (A)] as a mixture with carbaryl. this mixture optionally additionally comprising the various other formulation components as described above for the compositions comprising only the compound of formula (I) as active material.

The compositions comprising two active materials, one of formula (I) and the other being carbaryl, are particularly advantageous due to their broad spectrum with respect to all kinds of pests or parasites, in addition to darkling beetles, in particular spiders, ants, flies, ticks and white grubs (cockchafer grubs), as well as due to their speed of action (shock effect) and their persistence. These compositions with two active materials are particularly effective and inexpensive in their application.

These compositions provide an unexpected synergistic effect which potentiates the activity ranges of both a compound of formula (I) and carbaryl. The compositions achieve a high degree of pest control where the individual active materials are substantially inactive at low concentrations. This feature permits on the one hand a broadening of the activity spectrum against pests and on the other hand an enhancement of safety of application.

These compositions containing two active materials (of formula (I) + carbaryl), when they are concentrated compositions, generally comprise a) 0.000001 % to 10 % of active material of formula (I) preferably 0.00001 % to 10 %, more preferably 0.0001 to 0.001 %, and b) 0.0005 to 95% of carbaryl, preferably 0.5 to 90 %, more preferably 1 to 50 %. The solid formulations generally comprise from 0.5 to 60 % of carbaryl. The liquid formulations generally comprise from 5 to 90 % of carbaryl, preferably 40 to 80 %. For applications in private houses and gardens, the carbaryl content is generally between 1 and 20 %, preferably from 2 to 8 %; for applications by professionals, the content is generally between 10 and 50 %.

The compound of formula (1)/carbaryl ratio by weight is generally between 0.005 and 0.5, preferably between 0.01 and 0.1.

These two-constituent compositions are also particularly useful in treating lawns, gardens, private houses and various buildings.

The description of the invention will now be described in more detail, in its application, using embodiments intended to illustrate the invention in a nonlimiting way and to show how it can be implemented.

EXAMPLE 1

A poultry house was treated with water-dispersible granules containing 80 % of compound (A) at the rate of 150 g/ha = 1.5 g/100 m2. The treatment took place on the clean litter before the poultry was installed therein. The clean litter was essentially composed of straw.

On the day after the treatment, a group of chicks aged 1 to 2 days was installed in the rearing house at the rate of approximately 7 animals per m2.

The change in the population of darkling beetles (Alphitobius diaperinus) in the litter was regularly monitored using 9 homogeneously distributed traps. Measurements were carried out each week from the second week after the treatment until rearing was halted.

The total population of darkling beetles in the 9 traps of the treated poultry house varied between 11 and 96 until the 9th week after treatment whereas, in a similar but untreated poultry house, the population of darkling beetles (larvae and adults) oscillated between 1000 and 3000 at each counting point.

A mean control (or degree of destruction of the darkling beetles) of 95 to 97 % was thus obtained according to the invention, with a control of 86 % during the 10th week (end of a rearing cycle).

EXAMPLE 2

A 5 millilitre liquid mixture comprises the compound (A) and carbaryl, as well as water and acetone. This mixture is poured onto 40 g of wheat flour. The water/acetone ratio by volume is equal to 9/1. The amount of active material is such that there is a concentration of 0.4 ppm = 0.00004 % for the compound (A) and 100 ppm = 0.0001 % for the carbaryl.

10 adult Tenebrio molitor insects are placed in a flask containing the treated flour. The insects are observed to have a mortality of 100 %.

EXAMPLE 3

An application was carried out at the surface of poultry dung and of cow dung treated beforehand with fly larvae. At a dose of 25 ppm of compound (A), larval development of the flies was completely inhibited (100 % effectiveness with respect to untreated controls).

EXAMPLE 4

Receptacles containing a floor, poultry litter and poultry dung were treated with compound (A). These substrates were infested with larvae of the house fly and of the darkling beetle (Alphitobius diaperinus).

Treatments were carried out with doses of 1, 10 and 100 ppm administered on a single occasion using compositions of emulsion type or of granule type. 100 % inhibition of the development of the larval stages (fly or darkling beetle) was observed for doses of 10 and 100 ppm. 99 to 100 % inhibition of the development of the larval stages (fly or darkling beetle) was observed for the dose of 1 ppm.

EXAMPLE 5

Ten (10) gram pieces of potato were placed into individual jars. Carbaryl and compound (A) and combinations thereof, as shown below in Tables I and II, were substantially dissolved in a mixture of water: acetone-surfactant solution: DMF in a ratio of 90:9:1. The acetone-surfactant solution comprised acetone, Triton® 152, and Triton® 172 mixed in volumetric ratio of about 785:1:3. Two (2) mL aliquots of solution were added to 10 gm potato pieces and the treated potato pieces were dried overnight to provide concentrations of active materials in parts per million according to Table I and II. Adult Tenebrio molitor and a strip of paper towel 1 cm by 3 cm were added to each jar. Mortality was rated at 1 day after treatment.

A synergistic effect is obtained whenever the activity of the combination of the compound of formula (I) with carbaryl is greater than the sum of the activities of the individually applied compounds.

For example, the expected pesticidal activity We of a given combination of two pesticides can be caluculated as follows (q.v. Colby, S.R., "Calculating synergistic and antagonistic response of herbicide combinations". Weeds 15 1967 pp. 20-22): We = X + [Y•(100-X)]/100 wherein X is the percentage mortality, compared with untreated controls, after treatment with compound (A) at a rate p in parts per million; and Y is the percentage mortality, compared with untreated controls, after treatment by carbaryl at rate q in parts per million; and We is thus the expected mortality after treatment with compound (A) and carbaryl at a rate of application of p + q ppm. If the actually observed value is greater than the expected value We then there is synergism. Individual Materials Rate Cumpound(A) (ppm) % Mortality Rate Carbaryl (ppm) % Mortality 2 100 400 93 0.5 87 100 80 0.125 7 25 27 0.03 0 6.25 0
Combinations Rates of Compound (A),

Carbaryl (ppm)
Expected

% Mortality
Actual

% Mortality
0.125, 25 32 87 0.125, 6.25 7 80 0.03, 25 27 53 0.03, 6.25 0 13


Anspruch[de]
  1. Pestizide Zusammensetzung mit Carbaryl und einer Wirksubstanz der Formel (I):
    in der
    R1
    ein Halogenatom oder eine CN- oder Methylgruppe bedeutet,
    R2
    S(O)nR3, 4,5-Dicyanimidazol-2-yl oder Halogenalkyl bedeutet,
    R3
    Alkyl oder Halogenalkyl bedeutet,
    R4
    ein Wasserstoff- oder Halogenatom oder einen NR5R6-, S(O)mR7-, C(O)R7-, C(O)O-R7-, Alkyl-, Halogenalkyl-, OR8- oder -N=C(R9)(R10)-Rest darstellt,
    R5 und R6
    unabhängig voneinander ein Wasserstoffatom oder einen Alkyl-, Halogenalkyl-, C(O)-Alkyl-, Alkoxycarbonyl- oder S(O)rCF3-Rest darstellen, oder R5 und R6 gemeinsam einen zweiwertigen Alkylenrest, der durch ein oder zwei zweiwertige Heteroatome, wie Sauerstoff oder Schwefel, unterbrochen sein kann, bilden können,
    R7
    einen Alkyl- oder Halogenalkylrest darstellt,
    R8
    einen Alkyl- oder Halogenalkylrest oder ein Wasserstoffatom darstellt,
    R9
    einen Alkylrest oder ein Wasserstoffatom darstellt,
    R10
    eine Phenyl- oder Heteroarylgruppe, die gegebenenfalls durch ein oder mehrere Halogenatome oder ein oder mehrere Gruppen wie OH, -O-Alkyl, -S-Alkyl, Cyan oder Alkyl substituiert ist, darstellt,
    R11 und R12
    unabhängig voneinander ein Wasserstoff- oder Halogenatom und gegebenenfalls CN oder NO2 darstellen, wobei jedoch H oder Halogen bevorzugt sind,
    R13
    ein Halogenatom oder eine Halogenalkyl-, Halogenalkoxy-, S(O)qCF3- oder SF5-Gruppe darstellt,
    m, n, q und r
    unabhängig voneinander eine ganze Zahl 0, 1 oder 2 darstellen,
    X
    ein dreiwertiges Stickstoffatom oder einen C-R12-Rest darstellt, wobei die übrigen drei Valenzen des Kohlenstoffatoms einen Teil des aromatischen Rings bilden,
    mit der Maßgabe, daß, wenn R1 Methyl bedeutet, entweder R3 Halogenalkyl, R4 NH2, R11 Cl, R13 CF3 und X N bedeuten oder R2 4,5-Dicyanimidazol-2-yl, R4 Cl, R11 Cl, R13 CF3 und X =C-Cl bedeuten.
  2. Pestizide Zusammensetzung nach Anspruch 1, in deren Formel (I) R1 CN und/oder R3 Halogenalkyl und/oder R4 NH2 und/oder X CR12 und/oder R11 und R12 unabhängig voneinander ein Halogenatom und/oder R13 Halogenalkyl bedeuten.
  3. Pestizide Zusammensetzung nach einem der vorhergehenden Ansprüche, wobei es sich bei der Verbindung der Formel (I) um 1-[2,6-Cl2-4-CF3-Phenyl]-3-CN-4-[SO-CF3]-5-NH2-pyrazol handelt.
  4. Pestizide Zusammensetzung nach einem der vorhergehenden Ansprüche mit a) 0,000001% bis 10%, vorzugsweise 0,00001% bis 10%, stärker bevorzugt 0,0001 bis 0,001%, Wirksubstanz der Formel (I) und b) 0,0005 bis 95%, vorzugsweise 0,5 bis 90%, stärker bevorzugt 1 bis 50%, Carbaryl.
  5. Pestizide Zusammensetzung nach Anspruch 3 oder 4 in fester Form mit 0,5 bis 60% Carbaryl.
  6. Pestizide Zusammensetzung nach Anspruch 3 oder 4 in flüssiger Form mit 5 bis 90% Carbaryl.
  7. Zusammensetzung nach einem der Ansprüche 3 bis 6, in der das Gewichtsverhältnis von Verbindung der Formel (I) zu Carbaryl zwischen 0,005 und 0,5, vorzugsweise zwischen 0,01 und 0,1, liegt.
  8. Verfahren zur antiparasitären Behandlung von Orten, die von Tenebrionidae-Käfern befallen sind oder befallen werden können, bei dem eine wirksame Menge einer wie in einem der Ansprüche 1 bis 7 definierten Zusammensetzung auf diesen Ort ausgebracht wird.
  9. Verfahren nach Anspruch 8, wobei es sich bei den behandelten Orten um den Boden oder eine Einstreu oder Gülle oder einen Platz oder ein Gebäude oder einen Stall für die Aufzucht von Nutztieren handelt.
  10. Verfahren nach einem der Ansprüche 8 oder 9, wobei es sich bei den behandelten Orten um den Boden oder eine Einstreu oder Gülle oder einen Platz oder ein Gebäude oder einen Stall für die Aufzucht von Nutztieren, in den Geflügel eingestellt werden soll, handelt.
  11. Verfahren nach einem der Ansprüche 8 bis 10, wobei die behandelten Orte mit Alphitobius diaperinus befallen sind oder befallen werden können.
  12. Verfahren nach einem der Ansprüche 8 bis 11, wobei die behandelten Orte mit Dermestes maculatus, Tenebrio molitor oder einem Käfer der Familie Tenebrionidae befallen sind oder befallen werden können.
  13. Verfahren nach einem der Ansprüche 8 bis 12, wobei die Behandlung mit einer Häufigkeit von weniger als einmal pro Monat durchgeführt wird.
  14. Verfahren nach einem der Ansprüche 8 bis 13, wobei die Behandlung mit einer Häufigkeit durchgeführt wird, die einmal pro Aufzuchtzyklus nicht überschreitet.
  15. Verfahren nach einem der Ansprüche 8 bis 14, wobei die Behandlung ausgehend von einer Zusammensetzung in Form eines dispergierbaren Granulats oder einer Suspension oder eines emulgierbaren Konzentrats durchgeführt wird.
  16. Verfahren nach einem der Ansprüche 8 bis 15, wobei die Behandlung ausgehend von einer Zusammensetzung in Form eines dispergierbaren Granulats mit einer Dichte zwischen 0,2 und 0,8, vorzugsweise zwischen 0,3 und 0,6 und mit einer Größe zwischen 0,1 und 3 mm, vorzugsweise zwischen 0,3 und 1,5 mm, durchgeführt wird.
  17. Verfahren nach einem der Ansprüche 8 bis 16, wobei die Behandlung durch Ausbringung der Wirksubstanz der Formel (I) in einer Menge von 0,05 bis 100 mg pro m2, vorzugsweise zwischen 0,5 und 50 mg/m2, noch stärker bevorzugt zwischen 10 und 15 mg/m2, durchgeführt wird.
  18. Verfahren nach einem der Ansprüche 8 bis 17, wobei die Behandlung in Abwesenheit von Tieren durchgeführt wird.
  19. Verfahren nach einem der Ansprüche 8 bis 18, wobei ein Boden oder eine Einstreu oder Gülle mit einer Menge von 0,01 bis 50 mg Aktivsubstanz der Formel (I) pro kg gebrauchsfertige Einstreu, vorzugsweise in einer Menge von 0,1 bis 10 mg/kg, behandelt wird.
  20. Tiereinstreu mit einer wirksamen Menge einer nach einem der Ansprüche 1 bis 7 definierten antiparasitären Zusammensetzung.
  21. Geflügeleinstreu mit einer wirksamen Menge einer nach einem der Ansprüche 1 bis 7 definierten antiparasitären Zusammensetzung.
  22. Boden, Einstreu oder Gülle mit einer wirksamen Menge einer nach einem der Ansprüche 1 bis 7 definierten antiparasitären Zusammensetzung.
  23. Boden, Einstreu oder Gülle nach einem der Ansprüche 20 bis 22 mit zwischen 0,05 und 100 mg antiparasitärer Wirksubstanz der Formel (I) pro m2, vorzugsweise zwischen 0,5 und 50 mg/m2 und noch stärker bevorzugt zwischen 10 und 15 mg/m2.
  24. Einstreu nach einem der Ansprüche 20 bis 22 mit 0,01 bis 50 mg Wirksubstanz der Formel (I) pro kg gebrauchsfertige Einstreu, vorzugsweise 0,1 bis 10 mg/kg.
Anspruch[en]
  1. Pesticidal composition comprising carbaryl and an active material of formula (I):
    in which:
    R1
    is a halogen atom or a CN or methyl group;
    R2
    is S(O)nR3 or 4,5-dicyanoimidazol-2-yl or haloalkyl;
    R3
    is alkyl or haloalkyl;
    R4
    represents a hydrogen or halogen atom; or an NR5R6, S(O)mR7, C(O)R7 or C(O)O-R7, alkyl, haloalkyl or OR8 radical or an -N=C(R9)(R10) radical;
    R5 and R6
    independently represent a hydrogen atom or an alkyl, haloalkyl, C(O)alkyl, alkoxycarbonyl, S(O)rCF3 radical; or R5 and R6 can together form a divalent alkylene radical which can be interrupted by one or two divalent heteroatoms, such as oxygen or sulphur;
    R7
    represents an alkyl or haloalkyl radical;
    R8
    represents an alkyl or haloalkyl radical or a hydrogen atom;
    R9
    represents an alkyl radical or a hydrogen atom;
    R10
    represents a phenyl or heteroaryl group optionally substituted by one or a number of halogen atoms or groups such as OH, -O-alkyl, -S-alkyl, cyano or alkyl;
    R11 and R12
    represent, independently of one another, a hydrogen or halogen atom and optionally CN or NO2 but H or halogen are preferred;
    R13
    represents a halogen atom or a haloalkyl, haloalkoxy, S(O)qCF3 or SF5 group;
    m, n, q and r
    represent, independently of one another, an integer equal to 0, 1 or 2;

    X represents a trivalent nitrogen atom or a C-R12 radical, the other three valencies of the carbon atom forming part of the aromatic ring;

    with the proviso that, when R1 is methyl, then either R3 is haloalkyl,
    R4
    is NH2, R11 is Cl, R13 is CF3 and X is N; or else R2 is 4,5-dicyanoimidazol-2-yl,
    R4
    is Cl, R11 is Cl, R13 is CF3 and X is =C-Cl, is applied to the said site.
  2. Pesticidal composition according to Claim 1, in the formula
    • (I) of which R1 is CN and/or R3 is haloalkyl and/or R4 is NH2 and/or X is CR12 and/or R11 and R12 are, independently of one another, a halogen atom and/or R13 is haloalkyl.
  3. Pesticidal composition according to either of the preceding claims, in which the compound of formula (I) is 1-[2,6-Cl2-4-CF3phenyl]-3-CN-4-[SO-CF3]-5-NH2 pyrazole.
  4. Pesticidal composition according to any one of the foregoing claims, comprising a) 0.000001 % to 10 % of active material of formula (I) preferably 0.00001 % to 10 %, more preferably 0.0001 to 0.001 %, and b) 0.0005 to 95% of carbaryl, preferably 0.5 to 90 %, more preferably 1 to 50 %.
  5. Pesticidal composition according to Claim 3 or Claim 4, in the solid form and comprising from 0.5 to 60 % of carbaryl.
  6. Pesticidal composition according to Claim 3 or Claim 4, in the liquid form and comprising from 5 to 90 % of carbaryl.
  7. Composition according to one of Claims 3 to 6, in which the ratio by weight of compound of formula (I) with respect to carbaryl is between 0.005 and 0.5, preferably between 0.01 and 0.1.
  8. Process for the anti parasitic treatment of sites infested or capable of being infested by darkling beetles, in which an effective amount of a composition as defined in any of claims 1 to 7 is applied to the said site.
  9. Process according to claim 8, in which the treated sites are the floor or a litter or a liquid manure or a place or a building or a building for commercial rearing.
  10. Process according to any of claims 8 or 9, in which the treated sites are the floor or a litter or a liquid manure or a place or a building or a building for commercial rearing intended to receive poultry.
  11. Process according to one of claims 8 to 10, in which the treated sites are infested or capable of being infested by Alphitobius diaperinus.
  12. Process according to one of claims 8 to 11, in which the treated sites are infested or capable of being infested by Dermestes maculatus, Tenebrio molitor or a darkling beetle from the Tenebrionidae family.
  13. Process according to one of claims 8 to 12, in which the treatment is carried out at a frequency of less than once per month.
  14. Process according to one of claims 8 to 13, in which the treatment is carried out at a frequency not exceeding once per rearing cycle.
  15. Process according to one of claims 8 to 14, in which the treatment is carried out from a composition in the dispersible granule or suspension or emulsifiable concentrate form.
  16. Process according to one of claims 8 to 15, in which the treatment is carried out from a composition in the form of a dispersible granule with a density of between 0.2 and 0.8, preferably between 0.3 and 0.6, and with a size of between 0.1 and 3 mm, preferably between 0.3 and 1.5 mm.
  17. Process according to one of claims 8 to 16, in which the treatment is carried out by application of the active material of formula (I) at the rate of 0.05 to 100 mg per m2, preferably between 0.5 and 50 mg/m2 and more preferentially still between 10 and 15 mg/m2.
  18. Process according to one of claims 8 to 17, in which the treatment is carried out in the absence of animals.
  19. Process according to one of claims 8 to 18, in which a floor or litter or liquid manure is treated at the rate of 0.01 to 50 mg of active material of formula (I) per kg of ready-to-use litter, preferably of 0.1 to 10 mg/kg.
  20. Animal litter comprising an effective amount of an antiparasitic composition as defined in any of claims 1 to 7.
  21. Poultry litter comprising an effective amount of an antiparasitic composition as defined in any of claims 1 to 7.
  22. Floor, litter or liquid manure comprising an effective amount of an antiparasitic composition as defined in any of claims 1 to 7.
  23. Floor, litter or liquid manure according to one of Claims 20 to 22, comprising between 0.05 and 100 mg per m2, preferably between 0.5 and 50 mg/m2 and more preferentially still between 10 and 15 mg/m2 of antiparasitic active material of formula (I).
  24. Litter according to one of Claims 20 to 22, comprising between 0.01 and 50 mg of active material of formula (I) per kg of ready-to-use litter, preferably from 0.1 to 10 mg/kg.
Anspruch[fr]
  1. Composition pesticide comprenant un carbaryle et une substance active de formule (I) :
    dans laquelle :
    R1
    est un atome d'halogène ou un groupe CN ou méthyle ;
    R2
    est S(O)nR3 ou un 4,5-dicyano-imidazol-2-yle ou un halogénoalkyle ;
    R3
    est un alkyle ou un halogénoalkyle ;
    R4
    représente un atome d'hydrogène ou d'halogène ; ou un radical NR5R6, S(O)mR7, C(O)R7 ou C(O)O-R7, alkyle, halogénoalkyle ou OR8, ou un radical -N=C(R9)(R10) ;
    R5 et R6
    représentent indépendamment un atome d'hydrogène ou un radical alkyle, halogénoalkyle, C(O)alkyle, alcoxycarbonyle ou S(O)rCF3 ; ou R5 et R6 peuvent former conjointement un radical alkylène bivalent qui peut être interrompu par un ou deux hétéroatomes bivalents, tels qu'un oxygène ou un soufre ;
    R7
    représente un radical alkyle ou halogénoalkyle ;
    R8
    représente un radical alkyle ou halogénoalkyle ou un atome d'hydrogène ;
    R9
    représente un radical alkyle ou un atome d'hydrogène ;
    R10
    représente un groupe phényle ou hétéroaryle éventuellement substitué par un ou un certain nombre d'atomes d'halogène ou de groupes tels que OH, un -O-alkyle un -S-alkyle, un cyano ou un alkyle ;
    R11
    et R12 représentent, indépendamment l'un de l'autre, un atome d'hydrogène ou d'halogène et éventuellement CN ou NO2 mais H ou un halogène sont préférés ;
    R13
    représente un atome d'halogène ou un groupe halogénoalkyle, halogénoalcoxy, S(O)qCF3 ou SF5 ;
    m, n, q et r
    représentent, indépendamment les uns des autres, un entier valant 0, 1 ou 2 ;
    X
    représente un atome d'azote trivalent ou un radical C-R12, les trois autres valences de l'atome de carbone faisant partie du noyau aromatique ;
    à condition que, lorsque R1 est un méthyle, R3 soit un haloalkyle, R4 soit NH2, R11 soit Cl, R13 soit CF3 et X soit N ; ou R2 soit un 4,5-dicyano-imidazol-2-yle, R4 soit Cl, R11 soit Cl, R13 soit CF3 et X soit =C-Cl, est appliquée sur ledit site.
  2. Composition pesticide selon la revendication 1, dans la formule (I) de laquelle R1 est CN et/ou R3 est un halogénoalkyle et/ou R4 est NH2 et/ou X est CR12 et/ou R11 et R12 sont, indépendamment l'un de l'autre, un atome d'halogène et/ou R13 est un halogénoalkyle.
  3. Composé pesticide selon l'une ou l'autre des revendications précédentes, dans laquelle le composé de formule (I) est le 1-[2,6-Cl2-4-CF3phényl]-3-CN-4-[SO-CF3]-5-NH2-pyrazole.
  4. Composition pesticide selon l'une quelconque des revendications précédentes, comprenant a) de 0,000001 % à 10 % de substance active de formule (I), de préférence de 0,00001 % à 10 %, plus préférablement de 0,0001 % à 0,001 %, et b) de 0,0005 à 95 % de carbaryle, de préférence de 0,5 à 90 %, plus préférablement de 1 à 50 %.
  5. Composition pesticide selon la revendication 3 ou la revendication 4, sous la forme solide et comprenant de 0,5 à 60 % de carbaryle.
  6. Composition pesticide selon la revendication 3 ou la revendication 4, sous la forme liquide et comprenant de 5 à 90 % de carbaryle.
  7. Composition selon l'une des revendications 3 à 6, dans laquelle le rapport pondéral du composé de formule (I) par rapport au carbaryle est compris entre 0,005 et 0,5, de préférence entre 0,01 et 0,1.
  8. Procédé de traitement antiparasitaire de sites infestés ou susceptibles d'être infestés par des ténébrions, dans lequel une quantité efficace d'une composition telle que définie dans l'une quelconque des revendications 1 à 7 est appliquée sur ledit site.
  9. Procédé selon la revendication 8, dans lequel les sites traités sont le sol ou une litière ou un lisier ou un lieu ou un bâtiment ou un bâtiment pour élevage commercial.
  10. Procédé selon l'une quelconque des revendications 8 ou 9, dans lequel les sites traités sont le sol ou une litière ou un lisier ou un lieu ou un bâtiment ou un bâtiment pour élevage commercial destiné à recevoir de la volaille.
  11. Procédé selon l'une quelconque des revendications 8 à 10, dans lequel les sites traités sont infestés ou susceptibles d'être infestés par Alphitobius diaperinus.
  12. Procédé selon l'une quelconque des revendications 8 à 11, dans lequel les sites traités sont infestés ou susceptibles d'être infestés par Dermestes maculatus, Tenebrio molitor ou un ténébrion de la famille des Ténébrionidés.
  13. Procédé selon l'une des revendications 8 à 12, dans lequel le traitement est réalisé à une fréquence de moins d'une fois par mois.
  14. Procédé selon l'une des revendications 8 à 13, dans lequel le traitement est réalisé à une fréquence ne dépassant pas une fois par cycle d'élevage.
  15. Procédé selon l'une des revendications 8 à 14, dans lequel le traitement est réalisé à partir d'une composition sous la forme de granulé dispersable ou de suspension ou de concentré émulsifiable.
  16. Procédé selon l'une des revendications 8 à 15, dans lequel le traitement est réalisé à partir d'une composition sous la forme d'un granulé dispersable présentant une densité comprise entre 0,2 et 0,8, de préférence entre 0,3 et 0,6, et avec une taille comprise entre 0,1 et 3 mm, de préférence entre 0,3 et 1,5 mm.
  17. Procédé selon l'une des revendications 8 à 16, dans lequel le traitement est réalisé par application de la substance active de formule (I) au taux de 0,05 à 100 mg par m2, de préférence de 0,5 à 50 mg/m2 et encore plus préférablement de 10 à 15 mg/m2.
  18. Procédé selon l'une des revendications 8 à 17, dans lequel le traitement est réalisé en l'absence d'animaux.
  19. Procédé selon l'une des revendications 8 à 18, dans lequel un sol ou une litière ou un lisier est traité au taux de 0,01 à 50 mg de substance active de formule (I) par kg de litière prête à l'emploi, de préférence de 0,1 à 10 mg/kg.
  20. Litière animale comprenant une quantité efficace d'une composition antiparasitaire telle que définie dans l'une quelconque des revendications 1 à 7.
  21. Litière pour volaille comprenant une quantité efficace d'une composition antiparasitaire telle que définie dans l'une quelconque des revendications 1 à 7.
  22. Sol, litière ou lisier comprenant une quantité efficace d'une composition antiparasitaire telle que définie dans l'une quelconque des revendications 1 à 7.
  23. Sol, litière ou lisier selon l'une des revendications 20 à 22, comprenant entre 0,05 et 100 mg par m2, de préférence entre 0,5 et 50 mg/m2 et encore plus préférablement entre 10 et 15 mg/m2 de substance active antiparasitaire de formule (I).
  24. Litière selon l'une des revendications 20 à 22, comprenant entre 0,01 et 50 mg de substance active de formule (I) par kg de litière prête à l'emploi, de préférence de 0,1 à 10 mg/kg.






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